Prometheus gave the humans fire to allow them to have a better life, this is like the wife Frankenstein tries to create for his monster. Both led to a significant change in the creators lives and did in the end make them both be punished, Zeus created women and Pandora's box and Frankensteins monster haunts him and his bride.
Both creators try and challenge their Gods by creating and sustaining life and in Prometheus's because they seem to refuse to look accept their own limits.
Zeus gave Prometheus a physical imprisonment of chains, Frankensteins monster gives him a mental imprisonment with the guilt frankenstein feels over the deaths caused by his monster and the fact that he doesn't come clean about it.
Frankenstein isn't the only Prometheus in the novel though, Robert Walton the sailor is also one because in his desire to reach the North Pole his thirst for knowledge pushes him over the limits and he endangers himself and the crew of the ship and he ends up being punished through death as he isn't allowed to reach his goal. You could say that Walton was more like Prometheus than Frankenstein as Walton was willing to risk his own life for his goal as was Prometheus but Frankenstein ran from his creation.
